immunotherapy of relapsed and refractory solid tumors with
Pipeline Tessa TherapeuticsCancer Immunotherapy
Relapsed / refractory cHL that has failed at least 3 prior lines of therapy including chemotherapy brentuximab vedotin and PD-1 inihibitor. Patients may have previously received an autologous and / or allogeneic stem cell transplant CD30 positive tumor ECOG 0 to 1 or equivalent
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Initiation of First UniCAR Cellular Immunotherapy Study in
Dec 03 2020 · About the UniCAR-T-PSMA Study. This first-in-human phase I study is an open-label non-randomized dose-finding study designed to evaluate the safety and activity of UniCAR-T-PSMA in up to 16 patients with advanced relapsed/refractory PSMA-positive solid tumors
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CD19-Targeted CAR T Cells as Novel Cancer Immunotherapy
Immunotherapy for cancer has generated significant excitement owing to unprecedented responses in patients with chemotherapy-refractory acute leukemia and solid tumors. The mechanism of action for most immunotherapy includes the activation of a T-cell response against a malignancy.
Chat OnlineT-Cell Immunotherapy for Leukemia and Lymphoma (PLAT)
Neuroblastoma ENCIT is a phase 1 clinical trial testing T-cell therapy in children and adolescents with recurrent or refractory neuroblastoma. Solid tumors STRIvE-01 and -02 are phase 1 clinical trials testing T-cell therapy in children and young adults with relapsed or refractory solid tumors that express the protein EGFR or B7H3.
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Frontiers CART Immunotherapy Development Success and
Oct 17 2018 · Figure 1.Immune-mediated interactions in solid tumors and rationale for CART immunotherapy. (A) Release of cell debris and tumor antigens from malignant cells activates a cascade of host antitumor immune responses initiated by innate immune cells that release pro-inflammatory cytokines and contribute to tumor cell destruction. Among these cells are dendritic cells which capture tumor
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CARs Drive Immunotherapy for Multiple Myeloma Solid Tumors
Chimeric antigen receptor T cells (CARTs) are a novel cell-based therapy designed to direct host-derived T-cells against cancer cells through tumor-specific surface receptors. Our preliminary
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Immunotherapy combination treatments for leukemia
Farhad Ravandi M.D. professor of Leukemia is conducting a first-in-human study of the immunotherapy drug AMG 330 for relapsed or refractory (non-responsive to treatment) AML. The drug binds to a protein named CD33 that s on the surface of tumor cells and to a protein named CD3 that s on the surface of T cells and acts as a bridge
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Nivolumab in children and young adults with relapsed or
Nivolumab was safe and well tolerated in children and young adults and showed clinical activity in lymphoma. Nivolumab showed no significant single-agent activity in the common paediatric solid tumours. This study defines the recommended phase 2 dose and establishes a favourable safety profile for nivolumab in children and young adults which can serve as the basis for its potential study in
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Immunotherapy of Relapsed and Refractory Solid Tumors
of melanoma and survivin to patients with relapsed/refractory solid tumors. MATERIALS AND METHODS TAA-T products were generated from autologous peripheral blood and infused over three
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Frontiers CART Immunotherapy Development Success and
Oct 17 2018 · Figure 1.Immune-mediated interactions in solid tumors and rationale for CART immunotherapy. (A) Release of cell debris and tumor antigens from malignant cells activates a cascade of host antitumor immune responses initiated by innate immune cells that release pro-inflammatory cytokines and contribute to tumor cell destruction. Among these cells are dendritic cells which capture tumor
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414 Enhancing T cell therapy for patients with relapsed
Background Patients with relapsed or refractory Wilms tumor (WT) have poor prognoses with limited treatment options.1–3 Immunotherapy offers a promising alternative for targeted therapy but has been limited by immune evasion tactics.4–6 Adoptive cell therapy with patient-derived tumor-associated antigen-specific T cells (TAA-T) targeting 3 antigens (WT1 PRAME and survivin) has the
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Nivolumab in children and young adults with relapsed or
Nivolumab was safe and well tolerated in children and young adults and showed clinical activity in lymphoma. Nivolumab showed no significant single-agent activity in the common paediatric solid tumours. This study defines the recommended phase 2 dose and establishes a favourable safety profile for nivolumab in children and young adults which can serve as the basis for its potential study in
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Relapsed/Refractory mCRC Immunotherapy in MSI-High Tumors
Global Oncology News Join specialists as they discuss the lung cancer landscape Live Broadcast A New Treatment Option for Some Patients With Triple-Class Refractory Multiple Myeloma Neoadjuvant
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Immunotherapy in relapsed refractory Cancer World
Oct 27 2017 · A recent phase I/II trial investigated the combination of brentuximab vedotin with nivolumab in 42 patients with refractory or relapsed Hodgkin lymphoma including 40 with primary refractory disease. Of these 33 relapsed within one year and 26 relapsed
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Immunotherapy of Pediatric Solid Tumors Treatments at a
Feb 01 2020 · Finally checkpoint blockade using ICIs is now accepted as the standard immunotherapy modality for many adult solid tumors as well as Hodgkin lymphoma (5 19). However their
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Targeted immunotherapy for pediatric solid tumors
solid tumors remains a challenge with less than 20 survival.1 For those who survive late sequelae of chemotherapy and radi-ation therapy is the rule.2 Novel treatments including immuno-therapy are desperately needed that can impact survival while decreasing late effects. Although the number of solid tumor immunotherapy clinical trials in
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Solid tumors targeted in new CAR T-Cell immunotherapy
Solid tumors targeted in new CAR T-Cell immunotherapy trial Open to children and young adults with relapsed or refractory disease clinical trial extends immunotherapy to several types of EGFR
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Immunotherapy of Relapsed and Refractory Solid Tumors With
Purpose Tumor-associated antigen cytotoxic T cells (TAA-Ts) represent a new potentially effective and nontoxic therapeutic approach for patients with relapsed or refractory solid tumors. In this first-in-human trial we investigated the safety of administering TAA-Ts that target Wilms tumor gene 1 preferentially expressed antigen of melanoma and survivin to patients with relapsed
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Study of TJ011133 Subjects With Relapsed/Refractory
May 02 2019 · This is an open-label multi-center multiple dose Phase 1 study to evaluate the safety tolerability maximum tolerated dose (MTD) or maximum administered dose (MAD) pharmacokinetic (PK) pharmacodynamic and recommended Phase 2 dose (RP2D) of TJ011133 an anti-CD47 antibody in subjects with advanced relapsed or refractory solid tumors and lymphoma.
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A Study of LY Alone or With LY in
The purpose of this study is to evaluate the safety of the study drug known as LY an anti-T-cell immunoglobulin and mucin-domain domain-containing molecule-3 (TIM-3) antibody administered alone or in combination with LY an anti-programmed death ligand 1 (PD-L1) antibody in participants with advanced relapsed / refractory solid tumors.
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A Study of LY Alone or With LY in
The purpose of this study is to evaluate the safety of the study drug known as LY an anti-T-cell immunoglobulin and mucin-domain domain-containing molecule-3 (TIM-3) antibody administered alone or in combination with LY an anti-programmed death ligand 1 (PD-L1) antibody in participants with advanced relapsed / refractory solid tumors.
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About Immunotherapy Cancer Immuno Therapy CAR T-Cell
What Kinds of Cancer Can Be Treated with Immunotherapy Many different kinds of cancer can be treated with immunotherapy cancer procedures. CAR-T treatments are currently approved by the FDA to treat some forms of aggressive refractory non-Hodgkin lymphoma and for patients with relapsed or refractory acute lymphoblastic leukemia.
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Adoptive chemoimmunotherapy for the treatment of relapsed
1. J Immunother Emphasis Tumor Immunol. 1993 Apr13(3) 213-21. Adoptive chemoimmunotherapy for the treatment of relapsed and refractory solid tumors using ex vivo activated memory T cells
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A Study of LY Alone or With LY in
The purpose of this study is to evaluate the safety of the study drug known as LY an anti-T-cell immunoglobulin and mucin-domain domain-containing molecule-3 (TIM-3) antibody administered alone or in combination with LY an anti-programmed death ligand 1 (PD-L1) antibody in participants with advanced relapsed / refractory solid tumors.
Chat OnlineImmunotherapy in hematologic malignancies past present
Apr 24 2017 · The field of immunotherapy in cancer treatments has been accelerating over recent years and has entered the forefront as a leading area of ongoing research and promising therapies that have changed the treatment landscape for a variety of solid malignancies. Prior to its designation as the Science Breakthrough of the Year in 2013 cancer immunotherapy was active in the treatment of
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CARs Drive Immunotherapy for Multiple Myeloma Solid Tumors
Chimeric antigen receptor T cells (CARTs) are a novel cell-based therapy designed to direct host-derived T-cells against cancer cells through tumor-specific surface receptors. Our preliminary
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Solid tumors targeted in new CAR T-Cell immunotherapy trial
Aug 07 2018 · Seattle Children s has opened a chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory non
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Study of TJ011133 Subjects With Relapsed/Refractory
May 02 2019 · This is an open-label multi-center multiple dose Phase 1 study to evaluate the safety tolerability maximum tolerated dose (MTD) or maximum administered dose (MAD) pharmacokinetic (PK) pharmacodynamic and recommended Phase 2 dose (RP2D) of TJ011133 an anti-CD47 antibody in subjects with advanced relapsed or refractory solid tumors and lymphoma.
Chat OnlineIovance Biotherapeutics Immunotherapy for Solid Tumors
IOV-COM-202 is a Phase 2 clinical trial of Iovance TIL therapy (lifileucel LN-145 LN-144 and LN-145-S1) enrolling patients that have been diagnosed with histologically confirmed unresectable or metastatic melanoma recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) recurrent or metastatic non-small cell lung cancer (NSCLC) or relapsed or refractory NSCLC.
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Immunotherapy in relapsed refractory Cancer World
Oct 27 2017 · A recent phase I/II trial investigated the combination of brentuximab vedotin with nivolumab in 42 patients with refractory or relapsed Hodgkin lymphoma including 40 with primary refractory disease. Of these 33 relapsed within one year and 26 relapsed after one year (Herrera et al. 2016 American Society of Hematology Abstract #1105).
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